Our research interests primarily involve the application of synthetic and mechanistic organic chemistry to shed light on questions in biology and medicine. We are engaged in a program of chemical synthesis of variety of molecules with biological relevance. Much of our research emphasizes the design and synthesis of conformationally restricted analogs of biologically relevant peptides or portions of proteins. The rationale for the approach is that less flexible peptides may exhibit preferred interactions compared to the floppy peptides. The conformational analyses of these ligands employ both experimental (NMR, IR, CD and XRD) and theoretical approaches (conformational search/molecular mechanics) to arrive at a pharmacophore model.

​

​

​

​

​

​

​

​

​

​

​

​

​

​Organic Synthesis

​​​​​​

​

We extensively do multi-step organic synthesis. We design and synthesize unique classes of molecules that are not present in nature. Our group is involved in synthesis of complex molecules that give excellent training to students to attain expertise in the art of synthesis, purification and spectroscopic characterization. Our laboratory is also involved in:

​

Peptide design: 

One of our major efforts is to design peptide based molecules with structural or functional similarity to biomolecules. Our group is using several design strategies for developing

synthetic molecules with unusual functions.

 

​Protein mimetics:

We are developing several complex voluminous molecules and exploring their potential uses in medicinal and material sciences. Our group is involved in the synthesis of very complex molecular entities that can act like proteins.

​

 

 

 

 

 

 

 

 

​

​

 

Functional assembly:

Various assemblies and their morphological transformations are poorly understood. The chemical basis of morphogenesis is an area under investigation in our lab.

​

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Medicinal chemistry:

Our research group is investigating medicinal aspects of our synthesized biomimetic molecules. We intend to develop potent protein-protein interaction inhibitors based on our own developed strategies.

​

​

​

​

​

​

​

​

​